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This weight gain was suggested to be due to the appetite-boosting effects of ghrelin receptor activation [18]

Exacerbation of Oxidative Stress and Lipid Peroxidation: Androgens, via their receptor AR, can upregulate the expression and activity of NADPH oxidase (NOX) family subunits, leading to increased intracellular reactive oxygen species (ROS) production ( 2
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Curcumin also exhibits effects on cell death that do not rely on caspases (necroptosis), which is inherently linked to increased inflammatory activity

ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis
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