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As our dietary intake of nitrite is limited, most of our nitrite is generated from our microbiome as discussed in the context of the nitratenitriteNO pathway above and survives passage through the stomach and GI tract into circulation

To assess the impact of N-linked glycosylation on protein ligandability, we used tunicamycin (Tuni), a natural product that inhibits N-linked glycosylation through blockade of UDP- N -acetylglucosamine (GlcNAc) transfer to dolichol phosphate, a key step of N-linked protein glycosylation 26,27

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