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In the published literature, acetaminophen has been reported to be clastogenic when administered at 1,500 mg/kg/day to the rat model (3.6-times the MHDD, based on a body surface area comparison)
Alpha-lipoic acid, vitamin C, and vitamin E are added to enhance its bioavailability

Cancer 77 , 353358 (1998)

Addition of GM3 ganglioside to adipocytes inhibits insulin activation of the IRS-1
