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and females: SD vs WD: p = 0.000, Cohens d = 2.590

Practical Changes You May Notice While Taking Semaglutide Most users report noticeable appetite changes within 1-2 weeks of starting semaglutide, though the intensity builds over the first month

Store semaglutide between 2C and 8C (3646F)

The dual action is the most likely reason tirzepatide showed greater average weight loss in trial data, though individual response varies and many patients do exceptionally well on semaglutide