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To confirm whether tig-2 functions as a secreted factor to trigger gonadal longevity, we artificially overexpressed TIG-2::mCherry in the intestine, a tissue with little tig-2 expression (Wang et al, 2022), and found worms lifespan was indeed increased upon the intestinal overexpression of tig-2 (Fig

The results could lead to broader indications, further reinforcing its value in addressing chronic metabolic diseases

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Fu Z, Mui D, Zhu H, Zhang Y
