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For many individuals, successful weight loss is associated with improved self-esteem, physical functioning, quality of life, and reduced depressive symptoms

We now have a breakthrough class of drugs that can achieve profound weight loss equivalent to bariatric surgery, along with the side benefits of reducing cardiovascular risk factors (hypertension and hyperlipidemia), improving glucose regulation, reversing fatty liver, and the many detrimental long-term effects of obesity such as osteoarthritis and various cancers

It is only accessible within approved clinical trial settings, and patients should be cautious of unregulated sources offering it outside of trials

many clinicians advise backup contraception for several weeks after initiation and each escalation