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Tirzepatide GI profile Tirzepatide as a dual GLP-1/GIP agonist produces GI side effects somewhere between semaglutide and retatrutide in both rate and severity

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Wearing appropriate footwear and protective equipment reduces the risk of injuries during exercise

The safety profile, characterized by a higher incidence of gastrointestinal adverse events such as nausea, vomiting and diarrhea, is consistent with the drug's class but warrants especially careful consideration in a CKD population