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Activation of the renin-angiotensin system is an important homeostatic mechanism in states associated with volume depletion, and the use of inhibitors of these systems contributes to occurrence of acute kidney injury in subjects with volume depletion [149]
doi:10.1186/s12929-017-0379-z 154
For manufacturers, the focus is less about choosing between formats, and more about building platforms that can scale intelligently, adapt to future modalities, and remain compliant under increasing regulatory scrutiny
