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When to Contact Your Doctor Contact your healthcare provider immediately if you experience: severe or persistent abdominal pain, persistent vomiting or diarrhea (dehydration risk), inability to keep food or fluids down for 24+ hours, signs of pancreatitis (severe upper abdominal pain radiating to back), or any symptoms that significantly impact your daily life

Pharmacokinetics (How Long They Last): Semaglutide: Half-life: Approximately 7 days Reaches steady state: After 4-5 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 1-3 days after injection Tirzepatide: Half-life: Approximately 5 days Reaches steady state: After 4 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 8-72 hours after injection Both medications are designed for once-weekly dosing and maintain therapeutic levels throughout the week

Proactive hydration, nutritional strategies, and monitoring can maintain electrolyte balance and optimize treatment outcomes

Severe hypoglycaemia among patients with type 2 diabetes requiring emergency hospital admission: the Hypoglycaemia in Portugal Observational Study-Emergency Room (HIPOS-ER)