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A meta-analysis of dietary interventions shows high-protein intake (1.21.6 g/kg body weight) and soluble fiber (25 g/day) consistently increase fasting and postprandial GLP-1 levels
In some cases, doctors recommend gradual dose tapering instead of sudden discontinuation
This weight loss itself further improves insulin sensitivity and metabolic health
Discontinuation can be as high as 85% by the end of two years of treatment, according to a study conducted by Prime Therapeutics, a pharmacy benefit manager
