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J Am Acad Dermatol 80(4):10291072 Ethics declarations Ethics approval Ethics approval was not required for this study

Weekly injections are possible because of its long half-life, and its time-staggered effects on the different pathways enable a steadier, more predictable response with fewer sugar or energy highs and lows

Medical Intervention is Key to Sustaining Loss: FDA-approved GLP-1 medications, including semaglutide and tirzepatide, and non-surgical procedures like Endoscopic Sleeve Gastroplasty (ESG) and Gastric Balloons directly address the biological and hormonal barriers to weight loss

Side Effects: Retatrutide vs Tirzepatide Tolerability Both compounds share a common GI side effect profile nausea, vomiting, and diarrhea are the most frequently reported events, predominantly during dose escalation