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Description
The mechanism makes physiological sense
MicroRNA-214-5p aggravates sepsis-related acute kidney injury in mice
50,51 Clinical trials were performed in patients with moderate glycemic control (baseline A1c 7.2%8.5%) and may not be generalizable to patients with more uncontrolled diabetes
(3) Dose escalation effects and economic impossibility: Compensating for poor absorption primarily increases luminal concentration rather than systemic exposure, causing gastrointestinal class effects and inflating manufacturing costs to prohibitive levels before achieving therapeutic efficacy
