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Examples include: Medical contraindications to GLP-1 therapy Lack of clinical supervision No structured plan for muscle preservation Hormonal status not yet evaluated Reducing the dose does not remove contraindications or eliminate underlying medical risks

GLP-1 receptor agonists have shown strong efficacy in promoting weight loss and improving glycemic control, making them a preferred choice for patients with obesity, type 2 diabetes, and cardiovascular risk factors

Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling

Intrathecal injection of exenatide (1-100 ng) elicited dose-dependent antinociception in formalin-induced tonic flinching responses without affecting acute nociceptive phases [24] (Fig