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Both treatment groups also reported a significantly greater improvement in knee pain and physical function than the placebo group, as well as an improvement of cardiovascular risk factors, such as lower blood pressure

A subset of cultured cells expressed GLP- 1 receptor, and mice with a-cell specific GLP- 1 receptor knockout have mild glucose intolerance and higher glucagon secretion in response to glucose challenges than animals of the wild type, which may indicate that GLP- 1 directly affects this cell [69]

First, we presented endosomal co-localization in pancreatic islets of the GLP-1/GLP-1R complex, which is thought to be functional GLP-1R, and confirmed that this co-localization study was useful to detect the GLP-1/GLP-1R complex

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