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In clinical studies, researchers observed that levels of beta-hydroxybutyrate, a direct biomarker of fatty acid oxidation, increased two to threefold in a dose-related pattern at retatrutide doses of 4mg and higher

10.1016/j.diabres.2018.02.026 [EL 1

Weight Changes and Timeline Expectations After First Injection Significant weight loss typically begins in week 2 or 3 after your first injection, though some patients notice slight water-weight reduction in the first few days

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