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However, GLP-1 receptor agonists (like semaglutide) are often prescribed if metformin fails to properly regulate patients blood glucose levels and are designed to mimic glucagon-like protein-1 (GLP-1)

Weight Maintenance After Injectable# Recommendation : Orforglipron Reason : ATTAIN-MAINTAIN demonstrated that patients switching from injectable tirzepatide or semaglutide to orforglipron maintained their weight loss, validating oral step-down therapy

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