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Description
doi: 10.1016/j.nbd.2022.105824 420 ZhangX.SongW

CS catalyzes the initial reaction in the TCA cycle, a Claisen condensation-like reaction that uses acetyl-CoA and oxaloacetate (OAA) to generate citrate and CoA

Glutathione levels might get depleted by a variety of factors, including exposure to toxins, stress, and poor nutrition

Largely yes
