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Autonomic Shift: Over time, the repeated heat stress encourages a shift toward parasympathetic dominance, supporting better stress resilience
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An integrated modelcombining physical activity, dietary modulation (e.g., Mediterranean diet), and low-dose aspirin in selected patientsemerges as a promising strategy to shape the gut microbiota, reduce inflammation, and enhance anti-tumor immune surveillance, especially in biomarker-defined populations (e.g., PIK3CA-mutant CRC)
