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High levels of creatine tend to result from dehydration, but may also be caused by excessive exercise, inappropriate creatine supplementation, or a urinary tract infection

The second hypothesis (which is not mutually exclusive) is that mitochondrial malfunction is what causes the loss of SNpc DA neurons in PD
Experimental and Therapeutic Medicine

Structural Characterization of Melatonin as an Inhibitor of the Wnt Deacylase Notum
