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Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug

In fact, SOX9 was destabilized by the downregulation of selenium-responsive PRMT5 that sustains SOX9 stability via methylation 93

To evaluate the plaque-targeting capability of P-Mn/TI@mHSA, Cy5 dye was incorporated to prepare Cy5-labeled Mn/TI@mHSA