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Intervertebral disc degeneration: a focus on obesity and type 2 diabetes,

It can be a result of a metabolic insult which prompts the body to produce more GSH than normal, low intake of the amino acids methionine and cysteine (methionine predominantly comes from meat protein so those that dont eat meat or eat too little may be at higher risk), an inherently low level of the enzyme MTHFR, low intake of vitamins folate and B12, or increased detoxification of xenobiotics through the phase II liver reaction sulfation

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Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation