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Other lifestyle and health measures such as frailty and telomere length indicated that reverse causation is not likely

In vivo distribution and recognition of [ 68 Ga]Ga- LyP-1 in BLM-treated mice Mice that received BLM or saline were used to detect the in vivo distribution of [ 68 Ga]Ga-LyP-1 or [ 68 Ga]Ga-ARA at 1 h and 2 h after intravenous injection of radiolabeled peptides

doi: 10.1042/CS20030192

This extends beyond the system itself