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More recently, the degree of allelic diversity has also been revealed for several human UGT genes

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Dysregulation of these enzymes can lead to endocrine disorders, and in the context of PCOS, the enzyme CYP17A1 is crucial for androgen synthesis

Exposure to excessive bacteria-derived H 2 S has been proposed to cause intestinal epithelial injury and breakdown of the mucus barrier [1,76] as SRB reduce disulfide bonds which can denature the protective mucin in the biofilm [77] that normally lowers the probability of bacterial translocation by separating the epithelial layer from the luminal microbiota [78,79]