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These are just regular people who they assumed were relatively safe

Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial

Compared with Con-Neus mice, Lig-Neus recipients exhibited higher random blood glucose and glycated serum protein levels, impaired glucose tolerance, reduced insulin sensitivity, disrupted islet function, and increased pancreatic neutrophil infiltration (Fig S8cg)

Similarly, free radicals and ROS can promote programmed cell death or apoptosis through redox modification of proteins, carbohydrates, lipids, and nucleic acids