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2.2.2 Key driving factors 2.2.2.1 Iron overaccumulation The core driving factor of ferroptosis is the excessive accumulation of iron, and this process is mainly regulated by iron homeostasis regulators such as transferrin receptor (TFR), ferritin, and ferroportin (FPN) (Zhang et al., 2025c)

Finally, the review will discuss therapeutic strategies targeting GPX4 and ferroptosis, including pharmacological and gene therapies, and analyze the main challenges in this field and potential future research directions

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Cellular redox: A modulator of intestinal epithelial cell proliferation