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Moreover, RNA sequencing analysis of luteolin-treated asthma cell models and serum metabolic profiling of mice revealed that luteolin suppresses ALOX15 expression and modulates arachidonic acid metabolism
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Most endogenous H 2 S production is mediated by pyridoxal 5-phosphate-dependent enzymes: cystathionine -synthase (CBS), cystathionine -lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST, MPST) using l-cysteine, l-homocysteine or l-methionine as substrates [121]

Structure and kinetic analysis of H 2 S production by human mercaptopyruvate sulfurtransferase