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Melasma (also known as chloasma) is a complex form of hyperpigmentation that appears as symmetrical, web-like or patchy patterns in shades ranging from light brown to dark gray

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Compounds like acetate and succinate that are used in the oxygen respiration cannot be used when TMAO is terminal electron acceptor (DiChristina and DeLong, 1994) and on the contrary, acetate is a product of the anaerobic TMAO reduction (Ringo et al., 1984