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The kidney is one of the only two organs possessing sufficient gluconeogenic enzyme activities besides the liver, thus playing a significant role in glucose homeostasis in humans and animals 27

There are randomized trials showing that optimism-focused interventions can lead to meaningful, sustained changes in biological markers, including those tied to cardiovascular health. These interventions usually involve strategies such as mentally reframing challenges and practicing future-oriented thinking imagining realistic, positive outcomes rather than being pessimistic about what will happen, Cappon says

Wang R, Yu X, Cai H, Lu G, Gao D, Zhang M, Chai L, Yi W, Lv Z (2025) Gut microbiota alteration was related to subclinical hypothyroidism and dyslipidemia in mice

The International Menopause Societys lifestyle medicine guidance puts the spotlight exactly where it belongs: movement, sleep, healthy eating, emotional wellbeing, and sustainable daily habits
