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Deletion of glutathione biosynthesis genes in PAO1 in two separate studies have linked glutathione to the increased production of virulence factors like pyocyanin and persister cell formation, however they reported conflicting results about glutathiones effect on increasing or reducing biofilm formation (38, 39)

Once absorbed, NAC must undergo deacetylation to yield cysteine

Therefore, decreasing intracellular levels of GSH are associated with many diseases, such as age-related disorders and chronic diseases caused by oxidative stress [3]

doi: 10.4103/sjg.sjg_406_21 [DOI] [PMC free article] [PubMed] [Google Scholar] 55.Ammar MA, Abdou AMH