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Nrf2 can positively promote the synthesis of GSH and ferritin by upregulating relative genes like xCT, GCLC, and GCLM [80, 81]
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More recently, tofersen (QALSODY ), an antisense oligonucleotide targeting mutant SOD1 , has shown potential in reducing NfL levels and slowing functional decline, though concerns remain regarding inflammatory side effects and the failure of initial phase III trials [7678]
