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The main characteristics of Mller cell gliosis are cell hypertrophy, with thickening of both somas and processes, proliferation, as well as increased expression of cytoskeleton constituent proteins such as vimentin or GFAP, and decreased expression of GS ( During gliosis, Mller cells will also contribute to the formation of glial scars, which can inhibit the remodeling and normal regeneration of damaged retinal tissue (Lu et al., 2011
Glutathione transferases play a key role in catalyzing such reactions
Bacillithiol is a major buffer of the labile zinc pool in Bacillus subtilis
