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The headache phase follows the prodromal or aura stages of a migraine, marked by the activation and sensitization of the trigeminovascular system (TVS) and brainstem, leading to disrupted sensory processing and various neurological symptoms indicative of altered brain excitability (29)

These enzymes respectively dismutate superoxide radical, breakdown hydrogen peroxides and hydroperoxides to harmless molecules (H2O2/alcohol and O2)

A proximal AP-1 element (263 to 269) was found to be critical in mediating the effect of oxidative stress-induced increase in human GCLC transcription [98103]

The entry of pro-inflammatory cytokines and neurotoxic compounds into the CNS triggers an inflammatory cascade linked to reactive oxygen species (ROS) production