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Statistical analysis Statistical analyses were performed using R version 3.3.0 for Windows (The R Foundation for Statistical Computing, Vienna, Austria)

MR activation by aldosterone activates MAPK/p38 signaling, which decreases mitochondrial DNA content and ATP synthesis and increases oxidative stress, which is reversible with MR antagonists or antioxidants [31]

Studies have shown that combined hormonal birth controlmeaning the types that use estrogen and progesterone to prevent pregnancy (and come in the form of a pill, vaginal ring, or patch)can relieve many perimenopause symptoms, including: Menstrual irregularity Heavy menstrual bleeding Menstrual pain Vasomotor symptoms like hot flashes, heart palpitations, and migraines There are several hormonal birth control medications, as well as different forms (oral, patch, or ring), so talk to your provider about what makes most sense for you