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For example, the NCT04792021 clinical trial evaluated the pharmacological efficacy of NAC (600 mg twice daily) on oxidative stress, TNF-, and complications in patients with COVID-19 [58]

Future therapies that are neuroprotective and disease-modifying, including novel delivery paradigms by which drugs could be targeted to the CNS to destroy the mutant Huntingtin protein and to arrest disease progression are urgently needed

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However, in this case, the patients usually do not show symptoms of metabolic acidosis or hemolytic anemia, and antioxidant therapies are ineffective ( Table 2 Clinical features and laboratory data corresponding to patients diagnosed with GSSD in China