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Since B12 is processed in the liver, excessive amounts could potentially lead to complications in severe liver conditions

The adverse Drug Reaction Probability Scale, was rated at 7, so the reaction to vitamin B12 was probable

a degraded vial will not perform no matter how carefully it is dosed

2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Moher et al., 2009) and the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (Supplementary Table S1