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intermittent dosing regimens are not approved (Figure 1

Considering the good response to the first multimodal treatment, we decided to schedule subsequent treatment cycles of oral and topical treatment for 24 months, using the same agents and doses and reducing the frequency of peri-plaque penile injections with pentoxifylline 100 mg to one penile injection every month for 12 months (second cycle) and subsequently, we further reduced the frequency of penile injections to one injection every 2 months for 12 months (third cycle)

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Metabolic phenotypes are biochemical signatures that reflect an individuals unique metabolism and result from the interplay of ones genetic background, environment, microbiome, co-occurring conditions, and diet (25)