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Description
The stress-induced ROS can have effects on gene expression which may be imparted through a mitogen activated protein kinase (MAP) cascade for transcriptional regulation
Figueroa-Romero C, Hur J, Bender DE, Delaney CE, Cataldo MD, Smith AL et al (2012) Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis
It does not mean a complication is guaranteed, but it does help explain why your doctor may weigh a high GGT more heavily than you might expect from an enzyme that many patients think of as a secondary marker

10.1038/s41385-018-0021-8 6 BarbosaP.Abo El-MagdN
