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In addition to these intracellular inflammatory events, the integrity of the bloodbrain barrier (BBB) plays a decisive role in shaping the neuroinflammatory environment in PD [53]

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Studies such as ACCORD and EDIC have found that improving A1C levels does affect DPN progression and that intensive treatment caused a delay in the progression of neuropathy and reduced Michigan Neuropathy Screening Instrument score, loss of ankle jerks, and loss of light touch at the end of the study

To view a copy of this licence, visit About this article Cite this article Mahesh, S., Kaskel, F