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Smith LA, Alleman BC, Copley-Graves L (1994) Biological treatment options
Although there are still opposing reports, a widely accepted model is that synaptic NMDAR activation promotes cell survival whereas extrasynaptic activation triggers cell death and the tilted balance between synaptic and extrasynaptic NMDAR activity contributes to neuronal dysfunction such as acute cell trauma and chronic neurodegenerative diseases (Hardingham and Bading 2010)
Recent breakthroughs in nano-delivery systems have provided innovative strategies to address this challenge (Thakur et al., 2024)
[PubMed] [Google Scholar] 179.Strausfeld U, Labbe JC, Fesquet D, Cavadore JC, Picard A, Sadhu K, Russell P, Doree M
