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BUT, again, when ROS reaches higher pathological levels (so common), many problems arise, including (but not limited to)
However, mutations in the MTHFR gene typically result in a lack of folate required for methylation reactions
[DOI] [Google Scholar] Wang H
(4) There is a negative feedback regulation between glycogen synthase kinase 3 (GSK3) and Nrf2, Curcumin can promote the dissociation of Nrf2 from the complex by inhibiting the activity of GSK3, and then transfers into the nucleus (Li et al., 2020b)
