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In particular, tocotrienols have been reported to exert neuroprotective effects independent of classical antioxidant activity, including the regulation of glutamate excitotoxicity, enhancement of cerebral perfusion, and promotion of neuronal survival pathways (153)
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Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, et al
doi: 10.1056/NEJM199610313351805 67 BonapaceGConcolinoDFormicolaSStrisciuglioP
It can be: Mutations in the ATP8B1 gene are related to both the mild and severe forms of the disease
