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An engineered probiotic expressing metallothionein alleviates cadmium-induced liver injury by activating the Nrf2-Keap1 antioxidant pathway and restoring intestinal barrier integrity

doi: 10.1016/j.abb.2015.12.006

A differential metabolomics study suggests that the depletion of glutathione after low dose APAP (150mg/kg) is paralleled by elevation in the glutathione analogue ophthalmic acid, where the SH group of the cysteine residue of GSH is replaced with a CH3 group from 2-aminobutyrate [21]
