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Protocol approach: frozen shoulder (adhesive capsulitis) Goal: Reduce capsular fibrosis, restore range of motion, manage pain Peptide approach: BPC-157: 300 to 500 mcg daily for anti-inflammatory and tissue healing properties TB-500: 500 to 750 mcg twice weekly for systemic anti-inflammatory and tissue remodeling Note on relaxin-2: While the most specifically targeted peptide for this condition, it remains largely in the research phase and is not widely available through standard channels Duration: Twelve to sixteen weeks (frozen shoulder has a prolonged natural course) Critical addition: Aggressive physical therapy within pain tolerance

Lenaz G, Genova ML

A study published in Cell Metabolism shed light on the impact of AMPK activation on immune regulation act as Anti-inflammatory medium

Herein we found that both full-length sCSD and also the sB subregion suppressed both the phosphorylation of STAT3 and its ability to act as a transcriptional activator in CAV-1-silenced keratinocytes