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A 2-year multicenter randomized double-blind placebo-controlled trial was carried out by Reljanovic et al

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At high concentrations of ATP, the inhibitor site becomes occupied shifting the equilibrium of PFK-1 conformation to that of the T state decreasing the ability of PFK-1 to bind F6P

ROS and RNS production are important mechanisms of the innate immune system to combat invading pathogens due to their antimicrobial function
