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As emphasized, this was based on the compelling evidence collected from various models, a multitude of targets, and BPC 157s overwhelming action versus the simultaneous application of NO-agents, whether given alone, including L-NAME (NOS-blockade) and L-arginine (NOS-substrate, NO-over-stimulation), or together, including L-NAME+L-arginine, NO-inhibition, NO-overactivity, and NO-immobilization

Consquence : pas de conjugaison possible du glutathion, et donc un organisme qui aura des difficults traiter correctement les xnobiotiques qui nous entourent (mdicaments, pesticides, additifs alimentaires, etc.)

2j,k and Extended Data Fig