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In our view, the removal alone should not be understood as a new FDA determination of eligibility

For the R4 group, which resides next to the unoccupied S1 site in the co-crystal structure of DEL7 with 3CL protease, we added acetyl or tert -butyloxycarbonyl (Boc) groups onto the amine, aiming to occupy the S1 site to establish more favorable interactions

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