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Reported mutations in the ATM gene usually involve small deletions and insertions as well as single-nucleotide polymorphisms and lead to a complete absence or impaired function of the protein, mainly observed in sporadic breast cancer and hematological malignancies like T-cell prolymphocytic leukemia and mantle cell lymphoma (Lee 2024)

The phagocytized non-photosynthetic bacteria (symbionts) over eons evolved into mitochondria while the engulfed photosynthesizing bacteria became chloroplasts (known as the well-established endosymbiotic theory) of the early eukaryotes and during this process the melatonin-synthesizing capacity of the bacteria-derived organelles, both chloroplasts and mitochondria, was retained ( Figure 2 )

Changes observed in aged mice (12-months-old) include an upregulation of genes associated with the immune response, and a decrease in genes associated with environment probing and interactions with the ECM (Grabert et al., 2016