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Waist circumference as a vital sign in clinical practice: a consensus statement from the IAS and ICCR Working Group on Visceral Obesity

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The decrease in electron density weakens the OH bonds in the water molecules and makes it easier for them to lose a proton

And this is important both in terms of thinking about what effects you're going to get of taking a given peptide, if you decide to do that, as well as potential side effects, as well as things like how to adjust dosage and how long to take a peptide, whether or not to cycle the peptide, et cetera