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In order to compare the combined effect of metals and chelators in a comprehensive in vitro model, we engineered multidrug-resistant A431 cells overexpressing ABCB1/P-glycoprotein, ABCG2 or ABCC1/MRP1 (Fig S1, Fig S2, Fig S3)

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The Mediterranean diet (MD) exhibits remarkable diversity, encompassing substantial quantities of fresh vegetables, fruits, legumes, whole grains, nuts, olive oil, and fish, while maintaining a minimal consumption of processed foods and red meat