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Statins have shown the ability to inhibit tumor growth in many cancer types, including breast, ovarian, prostate, colon, leukemia, and lung cancers [80]

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IDH1 inhibitors were developed as part of the process of targeting mutant IDH1, with the Food and Drug Administration-approved mutant IDH1 inhibitor ivosidenib having activity also against the wild-type enzyme

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The degradation of ferritin by the action of nuclear receptor coactivator 4 (NCOA4)mediated autophagy, termed ferritinophagy, increases the level of labile iron pool or iron overload status, promoting Fenton reactions that generate iron (III) (Fe 3+ ) and the hydroxyl radical (OH ), thus elevating ROS levels and inducing oxidative damage (Fig

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This literature assistance was instrumental in the productive finishing point of this scholarly review work

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